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PhD student (f/m/d) in the group “Translational Protein Biochemistry”

German Center for Neurodegenerative Diseases (DZNE)
Baden-Württemberg Full Time
Reference: 5fe1efcf2651
The German Center for Neurodegenerative Diseases (DZNE) is a unique non-university research center which is dedicated to the subject dementia and all its areas, as well as other neurodegenerative diseases. The center compasses the full spectrum of fundamental research through population sciences to health care research. The DZNE stands for excellence in research and science management, translation of scientific results into practice, interdisciplinarity and internationalization. It is a research center within the Helmholtz Organization of German research centers. With over 1,000 employees from 60 nations, spread over 10 sites, the DZNE is one of the national and international leading research centers in its research field. For the DZNE site in Ulm, we are inviting applications for a PhD student (f/m/d) in the group “Translational Protein Biochemistry” Code 6010/2020/3 The main task of the research group Translational Protein Biochemistry (Prof. Dr. Tobias M. Böckers) is to validate the expression of relevant proteins in human tissue. In particular, components of the development of Amyotrophic lateral sclerosis (ALS) and Frontotemporal Dementia (FTD) diseases are of major interest. Furthermore, the research efforts under the keyword "Neurodegeneration as Synaptopathy" and the associated implications for new therapeutic approaches will be intensified. In addition, the role of proteins of postsynaptic density (PSD) in neurodegenerative diseases will be further investigated. For that purpose, patient derived induced pluripotent stem cells (hiPSC) will be differentiated into motor neurons for further analysis. Crispr/Cas9 technique will be applied on hiPSC for gene editing mimicking patient mutations and for the generation of knockout hiPSC of new genes potentially involved in the development of ALS. • Active participation in experimental work, experimental design, data generation, data analyses, and interpretation of results • Prepare and write manuscripts for publication in international scientific journals • Oral presentation of results on local, national, and international conferences • Experimental work includes molecular biology, especially cell culture of induced pluripotent stem cells • A keen interest in molecular biology and working with induced pluripotent stem cells • Experience in molecular biology and handling of pluripotent stem cells is advantageous • Successful candidates have a master’s degree in molecular biology, neuroscience, biochemistry (or a master’s degree in a related field) • English language is a prerequisite We are looking for candidates who are open-minded, creative team-player, enthusiastic, have strong analytical skills, think critically, and with good social skills. • Working in an international team within a stimulating research environment and with very well equipped laboratories • An international environment characterized by a strong focus on science and research • A high potential for the individual development of our employees • Targeted personnel development • Employment, payment and social benefits are consistent with those at other research institutes
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